Family Portrait

This picture of a southern African family members shows some of the variations that exist in human skin color. The shade of human skin can variety from an extremely light to really dark through every possible gradation in between. Together you could expect, the skin color trait has a more complex genetic communication than simply one gene v two alleles, i m sorry is the type of simple trait that Mendel learned in pea plants. Like skin color, countless other human being traits have actually more facility modes of inheritance than Mendelian traits. Such modes of inheritance are referred to as non-Mendelian inheritance, and also they incorporate inheritance of many allele traits, traits v codominance or incomplete dominance, and polygenic traits, amongst others, all of which are defined below.

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Environmental results on Phenotype

Many properties are affected by the environment and by genes. This might be specifically true for polygenic traits. For example, adult height might be negatively impacted by negative diet or disease during childhood. Skin color is one more polygenic trait. There is a wide range of skin color in human being worldwide. In enhancement to distinctions in skin color genes, distinctions in exposure to ultraviolet (UV) light cause some the the variations. As shown in Figure (PageIndex3), exposure come UV light darkens the skin.

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Figure (PageIndex3): Skin on the lower component of the arm is much darker in shade than protected skin close to the top as result of the effects of UV radiation.

Pleiotropy

Some genes affect more than one phenotypic trait. This is dubbed pleiotropy. Over there are plenty of examples the pleiotropy in humans. They typically involve essential proteins that are necessary for the normal breakthrough or work of more than one body organ system. An instance of pleiotropy in people occurs through the gene that codes for the main protein in collagen, a substance the helps kind bones. This protein is likewise important in the ears and eyes. Mutations in the gene result in difficulties not only in bones but likewise in this sensory organs, which is just how the gene"s pleiotropic results were discovered.

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Another instance of pleiotropy occurs with sickle cell anemia. This recessive hereditary disorder occurs as soon as there is a mutation in the gene that usually encodes the red blood cabinet protein referred to as hemoglobin. People with the disorder have two alleles because that sickle-cell hemoglobin, so named for the sickle shape (Figure (PageIndex4)) that their red blood cells take it on under details conditions such as physical exertion. The sickle-shaped red blood cells clog tiny blood vessels, resulting in multiple phenotypic effects, consisting of stunting of physical growth, particular bone deformities, kidney failure, and also strokes.