Medically the evaluation by Alana Biggers, M.D., MPH — written by Rachel Nall, MSN, CRNA on respectable 29, 2019

Some human being may problem that supplements containing large amounts that vitamin B-12 could be harmful. However, although part supplements — such as vitamin A or D — deserve to be harmful if a human being takes lock in excess, vitamin B-12 seems safe in big doses.

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Vitamin B-12 is an important for human being life as result of its role in making red blood cells and supporting the function of the brain and nerves.

If a who diet walk not provide enough vitamin B-12, a medical professional may indicate taking supplements, some of which contain more than the daily recommended dose. The human body does not save vitamin B-12, so acquisition extra is no harmful.

This post covers the recommended daily values for vitamin B-12, research right into the results of acquisition too lot B-12, and also how vitamin B-12 might affect pregnancy.


How lot vitamin B-12 is also much?

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Share on PinterestVitamin B-12 in large doses is not harmful due to the fact that the body does not store it.
The Office of dietary Supplements (ODS) perform not administer an upper limit for vitamin B-12. This is since people usually tolerate vitamin B-12 well through no undesirable side effects.

According come an post in the journal American family Physician, researcher have discovered that supplements include as lot as 1,000 time the recommended day-to-day allowance (RDA) are safe.

The human body does not absorb vitamin B-12 well. In fact, research says that the body absorbs just 9.7 micrograms (mcg) that a 500 mcg dose, i beg your pardon is simply 2%.

According to the ODS, the RDA that vitamin B-12 by period is as follows:

0–6 months: 0.4 mcg7–12 months: 0.5 mcg1–3 years: 0.9 mcg4–8 years: 1.2 mcg9–13 years: 1.8 mcg14 years and also older: 2.4 mcg

During pregnancy, the RDA that vitamin B-12 is 2.6 mcg. A woman requirements 2.8 mcg during lactation.


Can too lot vitamin B-12 reason side effects?

Specialists space not currently aware of any type of side effects linked with taking higher-than-recommended level of vitamin B-12.

Some researcher have even studied the potential side impacts of acquisition high sheep of vitamin B-12 for up to 5 years at a time. However, no studies have actually yet found any kind of adverse symptoms or trends of harm.

Specialists divide vitamins right into two categories: water soluble and fat soluble. Water dissolve vitamins dissolve in water and exit the human body via the urine. Vitamin B-12 is a water soluble vitamin, and this is one of the factors why greater vitamin B-12 levels space not toxic.

According to the Linus Pauling institute at Oregon State college in Corvallis, over there is at this time no evidence to suggest any type of adverse effects from:

taking oral vitamin B-12 in doses as high as 2 milligrams (mg)taking vitamin B-12 via injection in doses together high together 1 mg

Doctors have tendency to prescribe these higher dosages come treat problems related to very low vitamin B-12 levels, such as pernicious anemia.

Although vitamin B-12 appears, because that the most part, to be safe — also at greater dosages — an ext is not necessarily better.

There is no have to take really high sheep of vitamin B-12. Over there is no data to indicate that very high supplementation levels are any much more effective at an enhancing a who immune system or bodily functions if the person does not have a vitamin B-12 deficiency.


Healthcare specialists have not identified an upper limit blood level the vitamin B-12. The body will typically excrete overabundance vitamin B-12 the a human being gets native the diet or via supplements.

The human body does not absorb vitamin B-12 supplements very effectively. This way that even if a human takes very high amounts of vitamin B-12, your body quiet does not absorb a far-ranging amount.

In addition, taking part medications might impair the body’s capacity to absorb vitamin B-12. Examples of these drugs include:

H2 receptor antagonistsmetforminproton pump inhibitors

Vitamin B-12 supplements are safe come take during pregnancy.

In fact, the ODS recommend that women that follow strict vegetarian or vegetable diets must take vitamin B-12 supplements, as deficiency can severely influence the fetus.

For example, low vitamin B-12 level in pregnant women have the right to lead come an boosted risk that neural tube defects, preterm birth, preeclampsia, and also pregnancy loss, according to a review paper in The American journal of Clinical Nutrition.

The authors performed a literature review on how typically pregnant ladies were vitamin B-12 deficient. They found that, top top average, approximately 25% the pregnant women were deficient in vitamin B-12 across all trimesters.

Research in the newspaper American family Physician has discovered that the children of vitamin B-12 deficient women who breastfeed are much more likely to endure failure to thrive, developmental delays, anemia, and weakness.

Taking vitamin supplements or having actually vitamin B-12 injections may be protective against side results that doctors associate v deficiency.


Many people do no get sufficient vitamin B-12 from your diet.

Vitamin B-12 is naturally present in many animal products, consisting of meat, fish, dairy, and also eggs. Plant based resources of vitamin B-12 incorporate fortified milks and cereals, nutritional yeast, and vegan diffusion such as Marmite.

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However, doctors tend come recommend taking vitamin B-12 additional if a human being struggles to meet their everyday requirements. Civilization can discover vitamin B-12 additional in drugstores or choose from several species online.

Low vitamin B-12 levels can give rise to a number of health concerns, including: