In our recent question and also answer, the pharmacist discusses whether or no there is an interaction in between Benadryl and Zantac (ranitidine).

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Jones asked

Can you take it Benadryl and also Zantac together?


Benadryl (diphenhydramine) and Zantac (ranitidine) have the right to safely be taken together. Over there is no interaction between the two medications.

In fact, evidence says that combining a H1 blocker, like Benadryl and a H2 blocker, favor Zantac have the right to be a an extremely effective treatment for urticaria (hives).

Zantac (Ranitidine)

Zantac (ranitidine) is classified together a H2 blocker and also works by prevent histamine in ~ the H2 receptor.

While classified together a antihistamine, Zantac, as well as other H2 blockers, different from the antihistamines provided for allergies like Benadryl and Claritin, i m sorry block histamine at the H1 receptor.

H2 blockers work-related to reduce acid manufacturing by blocking parietal cells from being created to develop acid by histamine. H2 impede antihistamines are shown for the treatment of many conditions resulting from boosted acid manufacturing in the stomach including:

UlcersDyspepsiaGastroesophageal reflux condition (GERD)Esophagitis

Although H2 blockers are typically used because that stomach associated issues, evidence argues they are additionally beneficial for treating hives.

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Benadryl (Diphenhydramine)

Benadryl (diphenhydramine) is a an initial generation antihistamine, which are provided for their reasonably short term of activity (~4 to 8 hours) and their sedating properties.

In enhancement to its usage for dealing with seasonal allergy symptom such together a runny nose, Benadryl is additionally effective for treating symptoms of:

NauseaVomiting Vertigo associated with motion sickness.

As Benadryl has fairly far-ranging sedating effects, that is often used together a night time sleep aide and is common component of end the counter sleep assets such together ZzzQuil.

Benadryl starts to work about 20 come 30 minute after taking by mouth and also maximum blood concentrations are got to after 1 come 2 hours. The expression of action varies by individual but generally large 4 come 6 hours. Benadryl is generally well tolerated however can cause the following side effects:

SedationDizzinessRespiratory depression (rare)Taking Benadryl (Diphenhydramine) through Zantac (Ranitidine)

As pointed out above, the combination of Benadryl and Zantac is considered safe. The is not uncommon to use Benadryl for allergy symptoms or to treat insomnia and take Zantac because that unrelated stomach symptoms. In fact, both have been provided together for the treatment of hives.